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ILLUMINATING THE GENOME

The CRISPR/Cas9 system has been causing ripples in the scientific community ever since its mechanisms were reported in 2012. Commonly...

IDENTIFICATION OF NOVEL MIRNAS AND THEIR TARGET GENES FROM POPULUS SZECHUANICA INFECTED WITH MELAMPSORA LARICI-POPULINA

Abstract Two novel miRNAs were selected from a pre-constructed RNA library of Populus szechuanica infected with the foliar rust fungus...

 
 
 

THE PVT1/MIR-216B/BECLIN-1 REGULATES CISPLATIN SENSITIVITY OF NSCLC CELLS VIA MODULATING AUTOPHAGY AND APOPTOSIS

Abstract Purpose The efficacy of cisplatin-based chemotherapy remains an open question for chemo-resistance in non-small cell lung...

ERΑ UPREGULATES THE EXPRESSION OF LONG NON-CODING RNA LINC00472 WHICH SUPPRESSES THE PHOSPHORYLATION OF NF-ΚB IN BREAST CANCER

Abstract Purpose Low expression of long intergenic non-coding RNA LINC00472 in breast cancer is associated with aggressive tumors and...

 
 
 

GENERATION OF VIRUS‐RESISTANT POTATO PLANTS BY RNA GENOME TARGETING

Abstract CRISPR/Cas systems provide bacteria and archaea with molecular immunity against invading phages and foreign plasmids. The...

CRISPR/CAS9‐MEDIATED KNOCKOUT OF MICRORNA‐744 IMPROVES ANTIBODY TITER OF CHO PRODUCTION CELL LINES

Abstract MicroRNAs are non‐coding RNAs that serve as versatile molecular engineering tools to improve production cells by overexpression...

 
 
 

NOVARTIS PAYS $150M TO LICENSE AKCEA-IONIS CARDIAC DISEASE DRUG

Novartis has taken up its option to license antisense oligonucleotide TQJ230, triggering a $150 million payout that Akcea Therapeutics...

TARGET‐ACTIVATED DNA POLYMERASE ACTIVITY FOR SENSITIVE RNASE H ACTIVITY ASSAY

Abstract We herein described RNase H activity assay based on the target‐activated DNA polymerase activity. In the method, a detection...

 
 
 

ENHANCED CHO CLONE SCREENING: APPLYING TARGETED LOCUS AMPLIFICATION AND NEXT‐GENERATION SEQUENCING TECHNOLOGIES DURING CELL LINE DEVELOPMENT

Abstract Early analytical clone screening is important during CHO cell line development of biotherapeutic antibodies to select clones...

FTO CONTROLS REVERSIBLE M 6 AM RNA METHYLATION DURING SNRNA BIOGENESIS

FTO controls reversible m 6 Am RNA methylation during snRNA biogenesis FTO controls reversible m 6 Am RNA methylation during snRNA...

 
 
 

UFGI PUBLICATION ROUND-UP WEEK 2/18

RNA Binding Motif Protein 48 is required for U12 splicing and maize endosperm differentiation. Bai F, Corll J, Shodja DN, Davenport...

Asian Aquaculture Industry Benefits From Two New Genome Assemblies

ASIAN AQUACULTURE INDUSTRY BENEFITS FROM TWO NEW GENOME ASSEMBLIES

With their large brains, sophisticated sense organs and complex nervous systems, cephalopods could teach us a thing or two about learning,...

 
 
 

CUREVAC WALKS AWAY FROM ARCTURUS' UREA CYCLE DISORDER DRUG, BUT PARTNERSHIP REMAINS INTACT

Arcturus Therapeutics had a melodramatic 2018 - the San Diego biotech's CEO Joseph Payne was asked to leave for putting his interests...

IAmScience Ashley Meyer

IAMSCIENCE ASHLEY MEYER

Mariah Cox | Bond LSC Situated in the Bond Life Sciences Center is an almost empty research lab on the fourth floor, which to some...

 
 
 

EVOLUTIONARILY SIGNIFICANT A-TO-I RNA EDITING EVENTS ORIGINATED THROUGH G-TO-A MUTATIONS IN PRIMATES

Abstract Background Recent studies have revealed thousands of A-to-I RNA editing events in primates, but the origination and general...

CEL-ID: CELL LINE IDENTIFICATION USING RNA-SEQ DATA

Abstract Background Cell lines form the cornerstone of cell-based experimentation studies into understanding the underlying mechanisms...

 
 
 
Dewpoint Debuts with $60M to Target Protein Droplets Linked to Disease

DEWPOINT DEBUTS WITH $60M TO TARGET PROTEIN DROPLETS LINKED TO DISEASE

An exciting new area of cell biology research that has emerged in only the last decade has already spawned a startup, which launches...

Rapid and Sensitive Detection of the Interaction of Human Papillomavirus Virus‐Like Particles with Yeast Whole Cell RNA Using Biolayer Interferometry

RAPID AND SENSITIVE DETECTION OF THE INTERACTION OF HUMAN PAPILLOMAVIRUS VIRUS‐LIKE PARTICLES WITH YEAST WHOLE CELL RNA USING BIOLAYER INTERFEROMETRY

BLI biosensors with immobilized RNA detect and quantify the association of RNA with human papilloma virus virus‐like particles. BLI...

 
 
 
An RNA Origami Octahedron with Intrinsic siRNAs for Potent Gene Knockdown

AN RNA ORIGAMI OCTAHEDRON WITH INTRINSIC SIRNAS FOR POTENT GENE KNOCKDOWN

A 3D scaffolded RNA origami wireframe structure with intrinsic small interfering RNAs is characterized by transmission electron microscopy...

MAKING 'SENSE' OF THE 'CART BEFORE THE HORSE' IN MAMMALIAN CELLS

Researchers show that antisense RNA can mediated the formation of fusion genes.