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CRYSTAL STRUCTURE REVEALS HOW CURCUMIN IMPAIRS CANCER

Through x-ray crystallography and kinase-inhibitor specificity profiling, researchers reveal that curcumin, a natural occurring chemical...

 
 
 
Bio Roundup: Big Bucks For Calico, Data Dumps & The IPO Wave Rolls On

BIO ROUNDUP: BIG BUCKS FOR CALICO, DATA DUMPS & THE IPO WAVE ROLLS ON

If you're running a privately held biotech, the time to go public is now. Clinical data already in hand or not, biotechs have charged...

AstraZeneca's PARP Drug Is First to Help New Ovarian Cancer Patients

ASTRAZENECA'S PARP DRUG IS FIRST TO HELP NEW OVARIAN CANCER PATIENTS

Over the past few years, a new class of drugs known as “PARP” inhibitors have begun to change how ovarian cancer is treated. Data released...

 
 
 
New Way to Stop Drug-resistance in Prostate Cancer Identified

NEW WAY TO STOP DRUG-RESISTANCE IN PROSTATE CANCER IDENTIFIED

When one drug fails, a new door opens for the treatment of prostate cancer. The key resistance mechanism in prostate cancer and a molecular...

Immune Profile for Successful Cancer Immunotherapy Identified

IMMUNE PROFILE FOR SUCCESSFUL CANCER IMMUNOTHERAPY IDENTIFIED

Multiple immune cell types must be present in tumors for 'checkpoint inhibitor' therapies to be effective.

 
 
 
New Drug Combination for High-Risk Neuroblastoma

NEW DRUG COMBINATION FOR HIGH-RISK NEUROBLASTOMA

Researchers create novel combination as potential therapy for high-risk neuroblastoma. This combination is made of epigenetic inhibitors...

MEDIVIR DELAYS PIVOTAL HDAC TRIAL AS FDA DISCUSSIONS STALL

A year ago, Medivir was riding high after reporting midstage data that encouraged it to press ahead with a pivotal trial of its HDAC...

 
 
 
New Treatment Target for Aggressive Liver Cancer in Kids

NEW TREATMENT TARGET FOR AGGRESSIVE LIVER CANCER IN KIDS

New therapeutic strategy can target aggressive form of pediatric liver cancer called hepatoblastoma which can provide a strong rationale...

ASCO18: MIXED REACTION TO NEKTAR'S ‘CONFUSING' NKTR-214 TRIAL

Nektar Therapeutics' much-anticipated data from a study pairing its immuno-oncology prospect NKTR-214 with Bristol-Myers Squibb's checkpoint...

 
 
 
FDA Approves First of New Migraine Drugs

FDA APPROVES FIRST OF NEW MIGRAINE DRUGS

The FDA has approved the first in a new class of migraine drugs, called CGRP inhibitors, that aim to head off fight painful migraine...

 
 
 

TARGETING THE TRICKY PI3K PATHWAY IN CANCER, MEI GETS $75M TO PUSH PROGRAM THROUGH REGISTRATION STUDY

MEI Pharma $MEIP, a small public company in San Diego, has raised $75 million in a private sale of stock to push forward its PI3K inhibitor...

 
 
 

PUBLISHER CORRECTION: A SELECTIVE PEPTIDE INHIBITOR OF FRIZZLED 7 RECEPTORS DISRUPTS INTESTINAL STEM CELLS

Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells Publisher Correction: A...

Evelo IPO Raises $85M for Microbiome Drugs in Inflammation, Cancer

EVELO IPO RAISES $85M FOR MICROBIOME DRUGS IN INFLAMMATION, CANCER

Evelo Biosciences now has $85 million to spend on its pipeline of drugs that target the human microbiome. The Cambridge, MA-based biotech...

 
 
 
Over-the-counter acid-reflux drugs may cause pneumonia, study finds

OVER-THE-COUNTER ACID-REFLUX DRUGS MAY CAUSE PNEUMONIA, STUDY FINDS

Researchers from the University of Exeter found that taking proton pump inhibitors for at least a year is significantly linked to people...

 
 
 

IDENTIFICATION OF STRUCTURE-STABILIZING INTERACTIONS IN ENZYMES: A NOVEL MECHANISM TO IMPACT ENZYME ACTIVITY

Abstract Cruzain, a cysteine protease in the cathepsin family, is pivotal to the life-cycle of Trypanosoma cruzi , the etiological...

Erectile Dysfunction Drugs can Now Treat Various Other Conditions

ERECTILE DYSFUNCTION DRUGS CAN NOW TREAT VARIOUS OTHER CONDITIONS

Erectile dysfunction drugs such as phosphodiesterase-5 inhibitors can also be used to treat various other conditions like diabetes,...