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HIGH-DIMENSIONAL RENAL PROFILING: TOWARDS A BETTER UNDERSTANDING OF RENAL TRANSPLANT IMMUNE SUPPRESSION

Abstract Purpose of Review The goal of this review is to discuss new approaches to avoid calcineurin inhibitor /corticosteroids toxicities...

MECHANISMS OF PARP INHIBITOR RESISTANCE IN CANCER AND INSIGHTS INTO THE DNA DAMAGE RESPONSE

Editorial summary Inhibitors of poly polymerase have entered the clinic for the treatment of patients with cancers that lack homology-directed...

 
 
 

IMMUNE CHECKPOINT INHIBITORS IN MITF FAMILY TRANSLOCATION RENAL CELL CARCINOMAS AND GENETIC CORRELATES OF EXCEPTIONAL RESPONDERS

Abstract Background Microphthalmia Transcription Factor family translocation renal cell carcinoma is a rare RCC subtype harboring TFE3...

Relying on proton-pump inhibitors to relieve heartburn can leave you vulnerable to superbugs

RELYING ON PROTON-PUMP INHIBITORS TO RELIEVE HEARTBURN CAN LEAVE YOU VULNERABLE TO SUPERBUGS

Proton pump inhibitors are used by millions of people looking for heartburn relief, but new evidence shows that these drugs may come...

 
 
 
Kineta Gets $15M in New Cancer Drug Partnership with Pfizer

KINETA GETS $15M IN NEW CANCER DRUG PARTNERSHIP WITH PFIZER

Seattle biotech company Kineta continues to expand its roster of drug development partners, announcing on Monday it has entered into...

 
 
 
New Drug Combination Is More Effective For Treating Melanoma

NEW DRUG COMBINATION IS MORE EFFECTIVE FOR TREATING MELANOMA

Protein kinase inhibitors combined with ribonuclease compounds reduces the incidence of various side effects and prevents the emergence...

SYNTHESIS, CRYSTAL STRUCTURE, DFT STUDIES AND BIOLOGICAL ACTIVITY OF -3--1--3-HYDROXYPROP-2-EN-1-ONE

Nowadays, is emerging a new generation of highly promising inhibitors bearing the β-ketoenol functionality. The present work relates...

 
 
 

HYBRID CAFFEIC ACID DERIVATIVES AS MONOAMINE OXIDASES INHIBITORS: SYNTHESIS, RADICAL SCAVENGING ACTIVITY, MOLECULAR DOCKING STUDIES AND IN SILICO ADMET ANALYSIS

Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors have emerged...

 
 
 
Bio Roundup: Prices on TV, Novartis Hearts Radio, Warp Drive's End

BIO ROUNDUP: PRICES ON TV, NOVARTIS HEARTS RADIO, WARP DRIVE'S END

Two new battlegrounds emerged this week in the nation's ongoing drug pricing debate. The first involved television: The federal government...

 
 
 
Bio Roundup: Nobel Prizes, Duchenne Steps, Guardant's IPO & More

BIO ROUNDUP: NOBEL PRIZES, DUCHENNE STEPS, GUARDANT'S IPO & MORE

Cancer immunotherapy is all the rage these days. The idea of harnessing the immune system to treat cancer has sparked billions of dollars...

 
 
 
Nobel Medicine Prize Honors Cancer Immunotherapy Pioneers Allison & Honjo

NOBEL MEDICINE PRIZE HONORS CANCER IMMUNOTHERAPY PIONEERS ALLISON & HONJO

[ Updated 11:45 am ET Oct. 1 with comments from press conference ] Harnessing the immune system to fight cancer has transformed the...

Akrevia Launches with $30M for Next-Gen Cancer Immunotherapy

AKREVIA LAUNCHES WITH $30M FOR NEXT-GEN CANCER IMMUNOTHERAPY

What does the second generation of cancer immunotherapy look like? For Tim Clackson, president of a new biotech launching today, it...

 
 
 

IDENTIFICATION AND CHARACTERIZATION OF IN VIVO, IN VITRO AND REACTIVE METABOLITES OF VANDETANIB USING LC-ESI-MS/MS

Vandetanib is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the characterization...

Protease: The Enzyme that Makes Protein & Amino Acids Tick

PROTEASE: THE ENZYME THAT MAKES PROTEIN & AMINO ACIDS TICK

Maybe we don't give enzymes enough credit. They are required for literally every single chemical action that takes place in our bodies...

 
 
 
Lasker Awards Recognize Propofol Discovery, Women in Science Advocate & Others

LASKER AWARDS RECOGNIZE PROPOFOL DISCOVERY, WOMEN IN SCIENCE ADVOCATE & OTHERS

The winners of the U.S.'s most prestigious awards in biomedical sciences were announced today, for work in developing propofol, the...

New Screening Strategy May Help Develop Cure for Parkinson's Disease

NEW SCREENING STRATEGY MAY HELP DEVELOP CURE FOR PARKINSON'S DISEASE

New screening strategy identifies novel inhibitors which may cure Parkinson's disease which is a neurodegenerative disease caused by...