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New Progress in Representing Population Diversity in Human Genomes

NEW PROGRESS IN REPRESENTING POPULATION DIVERSITY IN HUMAN GENOMES

We're seeing real progress in efforts to better characterize genomic population diversity. That's particularly good news in light of...

GENOMIC ANALYSIS OF ANT DOMATIA-ASSOCIATED MELANIZED FUNGI

Abstract Several species of melanized fungi in the order Chaetothyriales live in symbiotic association with ants inhabiting plant cavities...

 
 
 

POST-DOCTORAL RESEARCH FELLOW, FUNCTIONAL CANCER GENOMICS | FRED HUTCHINSON CANCER RESEARCH CENTER

Nationwide, Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of...

New Way for On-the-spot Genome Analysis Developed

NEW WAY FOR ON-THE-SPOT GENOME ANALYSIS DEVELOPED

A novel method to take genome analysis offline has been developed by scientists. The ability to read the genome - all the DNA of an...

 
 
 
Uncovering Uncultivated Microbes in the Human Gut

UNCOVERING UNCULTIVATED MICROBES IN THE HUMAN GUT

A tree's growth is dependent on nutrients from the soil and water, as well as the microbes in, on, and around the roots. Similarly,...

STABLE H3K4ME3 IS ASSOCIATED WITH TRANSCRIPTION INITIATION DURING EARLY EMBRYO DEVELOPMENT

AbstractMotivationDuring development of the mammalian embryo, histone modification H3K4me3 plays an important role in regulating gene...

 
 
 
AGBT 2019: First Look at Early Access Results from the Sequel II System

AGBT 2019: FIRST LOOK AT EARLY ACCESS RESULTS FROM THE SEQUEL II SYSTEM

The PacBio team was honored to have the opportunity to give several talks at this year's Advances in Genome Biology & Technology conference....

A COMPARATIVE SURVEY OF MICROSATELLITES AMONG WILD AND DOMESTIC CAT PROVIDES VALUABLE RESOURCES FOR MARKER DEVELOPMENT

Abstract Information on the level and distribution of genetic variation is important for conservation plan of captive population of...

 
 
 

DETECTING AND PRIORITIZING BIOSYNTHETIC GENE CLUSTERS FOR BIOACTIVE COMPOUNDS IN BACTERIA AND FUNGI

Abstract Secondary metabolites produced by fungi and bacteria have long been of exceptional interest owing to their unique biomedical...

REGULATORY NETWORK RECONSTRUCTION OF FIVE ESSENTIAL MICRORNAS FOR SURVIVAL ANALYSIS IN BREAST CANCER BY INTEGRATING MIRNA AND MRNA EXPRESSION DATASETS

Abstract Although many of the genetic loci associated with breast cancer risk have been reported, there is a lack of systematic analysis...

 
 
 

ILLUMINATING THE GENOME

The CRISPR/Cas9 system has been causing ripples in the scientific community ever since its mechanisms were reported in 2012. Commonly...

NANOSCALE MONITORING OF MITOCHONDRIA AND LYSOSOME INTERACTIONS FOR DRUG SCREENING AND DISCOVERY

Abstract Technology advances in genomics, proteomics, and metabolomics largely expanded the pool of potential therapeutic targets....

 
 
 

CARDIAC PROTEOMICS REVEALS THE POTENTIAL MECHANISM OF MICROTUBULE ASSOCIATED PROTEIN 4 PHOSPHORYLATION-INDUCED MITOCHONDRIAL DYSFUNCTION

Abstract Background Our previous work suggested that microtubule associated protein 4 phosphorylation led to mitochondrial dysfunction...

How DNA Ancestry Testing is Like the Wheel of Fortune: Filling in the Blanks

HOW DNA ANCESTRY TESTING IS LIKE THE WHEEL OF FORTUNE: FILLING IN THE BLANKS

“Ricki, we have another one.” AncestryDNA has spit out yet another half-sibling. I'm a curious hybrid, a geneticist and an “NPE” -...

 
 
 
GIAB Expands Variant Call Sets with SMRT Sequencing Results

GIAB EXPANDS VARIANT CALL SETS WITH SMRT SEQUENCING RESULTS

Genome in a Bottle Consortium You may have missed last week's Advances in Genome Biology & Technology conference in sunny Marco Island,...

Beam Brings In $135M to Turn CRISPR Base Editing into Drugs

BEAM BRINGS IN $135M TO TURN CRISPR BASE EDITING INTO DRUGS

Beam Therapeutics made a splash last year when it launched with $87 million to develop medicines that use a more precise form of CRISPR...

 
 
 

CHECKING DNA BASE EDITOR'S MISTAKES AND TRICKS TO REDUCE THEM

Scientists have identified the mistake-rate of DNA editing tools, based on CRISPR and known as adenine base editors. Assessing the...

BOYCE THOMPSON INSTITUTE LAUNCHES NEW PLANT GENOME EDITING DATABASE

Recently developed gene editing tools like CRISPR/Cas enable plant scientists to figure out the functions of myriad plant genes. While...

 
 
 

IMPROVED DETECTION ALGORITHM FOR COPY NUMBER VARIATIONS BASED ON HIDDEN MARKOV MODEL

Abstract Aiming at the problems of parameter optimization and insufficient utilization of split reads in the detection for copy number...