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SOLVE-RD Funded to Improve Diagnosis of Rare Disease with New Tools Including Long-Read Sequencing

SOLVE-RD FUNDED TO IMPROVE DIAGNOSIS OF RARE DISEASE WITH NEW TOOLS INCLUDING LONG-READ SEQUENCING

The SOLVE-RD research program , a collaboration of 21 participant organizations in 10 nations, announced it has received a €15 million...

PRODUCTION SUPPORT LEAD

LGC provides a range of measurement products and services which underpin the safety, health and security of the public, including reference...

 
 
 
When A Single Reference is Not Enough

WHEN A SINGLE REFERENCE IS NOT ENOUGH

Maize is amazingly diverse. A study comparing genome segments from two inbred lines, for instance, revealed that half of the sequence...

GENETIC RELATIONSHIPS AMONG VIETNAMESE LOCAL PIGS INVESTIGATED USING GENOME-WIDE SNP MARKERS

Summary Vietnam is one of the most important countries for pig domestication, and a total of 26 local breeds have been reported. In...

 
 
 
CRISPR Recovery? “Furor” Briefly Snips $500M From Companies' Values

CRISPR RECOVERY? “FUROR” BRIEFLY SNIPS $500M FROM COMPANIES' VALUES

Is the J.P. Morgan CRISPR rollercoaster ride over? As rain fell heavily in San Francisco Monday, the first day of the massive healthcare...

Carnivorous Plant Relies on Tandem Duplications for Adaptation

CARNIVOROUS PLANT RELIES ON TANDEM DUPLICATIONS FOR ADAPTATION

Photo by Kevin Thiele Scientists from the University at Buffalo, Nanyang Technological University, and other institutions published...

 
 
 

TUMOR PURITY QUANTIFICATION BY CLONAL DNA METHYLATION SIGNATURES

AbstractMotivationControlling for tumor purity in molecular analyses is essential to allow for reliable genomic aberration calls, for...

GENOME-WIDE SCREENING OF DNA METHYLATION IN BOVINE BLASTOCYSTS WITH DIFFERENT KINETICS OF DEVELOPMENT

Abstract Background The timing of the first cell divisions may predict the developmental potential of an embryo, including its ability...

 
 
 

SCIENTISTS USE CRISPR TO MODIFY PROMOTERS AND BOOST CROP YIELDS

Daniel Rodríguez-Leal, a 2016 Pew Latin American fellow, and Zachary Lippman of Cold Spring Harbor Laboratory used CRISPR genome-editing...

Real World Native Biocrusts: Microbial Metabolism

REAL WORLD NATIVE BIOCRUSTS: MICROBIAL METABOLISM

Biocrust amongst one of its many natural habitats, taken about 20 miles from the sampling site. Credit: Tami Swenson Arid lands, which...

 
 
 
Collaborative Effort Results in High-Quality Mosquito Genome, Raising Hope for Infectious Disease Control

COLLABORATIVE EFFORT RESULTS IN HIGH-QUALITY MOSQUITO GENOME, RAISING HOPE FOR INFECTIOUS DISEASE CONTROL

In an unprecedented crowd-sourced effort stoked by social media, 72 scientists collaborated via 25 conference calls and 3,323 emails...

FAST GENOMIC PREDICTION OF BREEDING VALUES USING PARALLEL MARKOV CHAIN MONTE CARLO WITH CONVERGENCE DIAGNOSIS

Abstract Background Running multiple-chain Markov Chain Monte Carlo provides an efficient parallel computing method for complex Bayesian...

 
 
 

SIMULATING AUTOSOMAL GENOTYPES WITH REALISTIC LINKAGE DISEQUILIBRIUM AND A SPIKED-IN GENETIC EFFECT

To evaluate statistical methods for genome-wide genetic analyses, one needs to be able to simulate realistic genotypes. We here describe...

GENETIC VARIATION ASSOCIATED WITH HEALTHY TRAITS AND ENVIRONMENTAL CONDITIONS IN VACCINIUM VITIS-IDAEA

Abstract Background Lingonberry , one of the least studied fruit crops in the Ericaceae family, has a dramatically increased worldwide...

 
 
 

AEROBIC PROTEOBACTERIAL METHYLOTROPHS IN MOVILE CAVE: GENOMIC AND METAGENOMIC ANALYSES

Abstract Background Movile Cave is a unique ecosystem where the food web is sustained by microbial primary production, analogous to...

CELL-TYPE-SPECIFIC GENE EXPRESSION PATTERNS IN THE KNEE CARTILAGE IN AN OSTEOARTHRITIS RAT MODEL

Abstract Osteoarthritis is a chronic degenerative disease that leads to joint failure, pain, and disability. Gene regulation is implicated...

 
 
 

ENTEROVIRUS-ASSOCIATED CHANGES IN BLOOD TRANSCRIPTOMIC PROFILES OF CHILDREN WITH GENETIC SUSCEPTIBILITY TO TYPE 1 DIABETES

Abstract Aims/hypothesis Enterovirus infections have been associated with the development of type 1 diabetes in multiple studies, but...

INTERGENIC DISEASE-ASSOCIATED REGIONS ARE ABUNDANT IN NOVEL TRANSCRIPTS

Genotyping of large populations through genome-wide association studies has successfully identified many genomic variants associated...

 
 
 

IDENTIFICATION OF COPY NUMBER VARIATIONS AND TRANSLOCATIONS IN CANCER CELLS FROM HI-C DATA

AbstractMotivationEukaryotic chromosomes adapt a complex and highly dynamic three-dimensional structure, which profoundly affects different...

PHANDANGO: AN INTERACTIVE VIEWER FOR BACTERIAL POPULATION GENOMICS

AbstractSummaryFully exploiting the wealth of data in current bacterial population genomics datasets requires synthesizing and integrating...